Key result
Low daytime SBP on antihypertensives is linked to ~4-fold greater cognitive decline.
Why the study?
Does low daytime systolic blood pressure increase cognitive decline in older patients with dementia and MCI treated with antihypertensive drugs?
Population
172 older patients with overt dementia and mild cognitive impairment, mean age 79 years, from 2 outpatient…
Comparison
Lowest tertile of daytime systolic blood… vs Intermediate tertile and highest tertile of…
Design
Cohort
Follow-up
median 9 months
Authors
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May warrant caution with low daytime SBP targets in treated older adults with MCI/dementia; leaves open causality and optimal goals.
Cohort (n=172)
Yes
Does low daytime systolic blood pressure increase cognitive decline in older patients with dementia and MCI treated with antihypertensive drugs?
Absolute Event Rate: -2.8% vs -0.7%
p-value: p=0.002
Low daytime systolic blood pressure (≤ 128 mm Hg) is associated with greater cognitive decline in older patients with dementia or MCI who are treated with antihypertensive drugs.
Mossello et al. (2015) conducted a cohort in Dementia and mild cognitive impairment (MCI) (n=172). Low daytime systolic blood pressure (≤ 128 mm Hg) and antihypertensive drugs vs. Intermediate (129-144 mm Hg) and highest (≥ 145 mm Hg) tertiles of daytime SBP was evaluated on Cognitive decline, defined as a Mini-Mental State Examination (MMSE) score change between baseline and follow-up (p=0.002). Low daytime systolic blood pressure (≤128 mm Hg) in patients treated with antihypertensive drugs was associated with greater cognitive decline (MMSE change -2.8 vs -0.7; P=0.002).
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