Key result
Upgrading from single right ventricular to biventricular pacing significantly improved NYHA functional class by 18%, 6-minute walk distance by 29%, and quality of life by 19% in advanced CHF.
Why the study?
Does upgrading to biventricular pacing improve functional status and echocardiographic measurements in permanently paced patients with worsening heart failure and ventricular dyssynchrony?
RCT (n=56)
Single-blind
Cross-over
Does upgrading to biventricular pacing improve functional status and echocardiographic measurements in permanently paced patients with worsening heart failure and ventricular dyssynchrony?
Upgrading from right ventricular to biventricular pacing significantly improves symptoms, exercise tolerance, and quality of life in chronically paced patients with advanced heart failure and mechanical dyssynchrony.
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Supports upgrading to BiV pacing in RV-paced patients with advanced HF and dyssynchrony; extends CRT evidence to upgrade scenarios.
Leclercq et al. (2007) conducted an RCT in Advanced congestive heart failure (n=56). Biventricular (BiV) stimulation vs. Conventional, single right ventricular (RV) stimulation was evaluated on Functional status, arrhythmias, and standard echocardiographic measurements. Upgrading from single right ventricular to biventricular pacing significantly improved NYHA functional class by 18%, 6-minute walk distance by 29%, and quality of life by 19% in advanced CHF.
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