Key result
Blood pressure shows a controversial association with Alzheimer's disease risk, requiring large randomized trials.
Why the study?
Is blood pressure associated with the risk of Alzheimer's disease?
Is blood pressure associated with the risk of Alzheimer's disease?
Current evidence on the association between blood pressure and Alzheimer's disease is conflicting, highlighting the need for large, standardized prospective studies.
Insufficient evidence to guide BP management for Alzheimer's prevention; leaves open the association pending large RCTs.
Alzheimer disease is one of the most common neurodegenerative disorder, and the incidence is increasing. Many epidemiologic studies have considered the association between blood pressure and Alzheimer disease, yet the relationship is still controversial. The objective of this study was to validate whether or not blood pressure is indeed associated with AD. We compared different prospective studies and ultimately found that it is also a controversial issue. Large prospective double-blinded and placebo-controlled studies conducted with the use of standardized outcome measures in different levels are necessary to assess the association of blood pressure and Alzheimer disease.
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Yuan et al. (2015) conducted a review in Alzheimer's Disease. Blood pressure was evaluated on Risk of Alzheimer's Disease. A review of prospective studies found that the association between blood pressure and Alzheimer's disease remains controversial, highlighting the need for large randomized controlled trials.
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