What question did this study set out to answer?

To determine how a physical conditioning program affects the distribution of cardiac output and regional blood flow at rest and during exercise in patients with coronary artery disease.

October 1, 1970Circulation

Effects of Training on the Distribution of Cardiac Output in Patients with Coronary Artery Disease

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Why the study?

Does a physical training program alter cardiac output distribution and regional blood flow in patients with coronary artery disease?

Population

9 patients with coronary artery disease (7 completed the training program)

Comparison

Physical training program of 4 to 10 weeks'… vs Baseline values before training

Design

Cohort

Follow-up

4 to 10 weeks

Authors

JCJan ClausenMedizinische Hochschule Hannover JTJ. Trap‐JensenFrederiksberg Hospital

Discussion

Member takes

Implication

Supports training-induced peripheral adaptations reducing submaximal myocardial work in CAD; leaves open outcome benefits pending RCTs.

Key Points

To determine how a physical conditioning program affects the distribution of cardiac output and regional blood flow at rest and during exercise in patients with coronary artery disease.
Evaluated cardiac output, muscle blood flow, and hepatic blood flow at rest and during exercise in 9 patients with coronary artery disease.
Repeated measurements after a 4- to 10-week physical training program in 7 patients.
At moderate workloads, physical training reduced cardiac output by 13.1% and muscle blood flow by 14.9%, normalizing the oxygen uptake-to-cardiac output relationship from hyperkinetic to normal.
During heavy exercise, training increased cardiac output by 5.5% and maximal muscle blood flow by 8.6%, while hepatic blood flow exhibited a less pronounced reduction across workloads (difference, 7.2%).

Structured PICO

Does a physical training program alter cardiac output distribution and regional blood flow in patients with coronary artery disease?

Population

9 patients with coronary artery disease (7 completed the training program)

Intervention

Physical training program of 4 to 10 weeks' duration

Comparator

Baseline values before training (pre-post comparison)

Outcome

Cardiac output distribution at rest and during exercise (measured by cardiac output, hepatic blood flow, and muscle blood flow)surrogate

Physical training in patients with coronary artery disease induces peripheral regulatory alterations that reduce myocardial pressure-work at submaximal loads.

Cite This Study

Clausen et al. (1970) studied this question.

synapsesocial.com/papers/6a0ee0d906ecbe833447ea13 https://doi.org/10.1161/01.cir.42.4.611

Topics

Coronary artery disease

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Effects of Training on the Distribution of Cardiac Output in Patients with Coronary Artery Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Effects of Training on the Distribution of Cardiac Output in Patients with Coronary Artery Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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