Early- Versus Newer-Generation Transcatheter Mitral Valve Edge-to-Edge Repair Systems

Figures

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  Figure 1. MR Grades During Follow-Up Bar graphs comparing mitral regurgitation (MR) severity between early- and newer-generation transcatheter mitral valve edge-to-edge repair systems at discharge, 1 month, and 1 year. The progressively darker shades of blue correlate with increasing grades of MR, ranging from 0 to 4+. DMR = degenerative mitral regurgitation; FMR = functional mitral regurgitation.

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  Figure 2. Clinical Outcomes of Early- vs Newer-Generation M-TEER System Kaplan-Meier curves illustrating 2-year event-free survival rates in patients treated with early- (red) and newer-generation (blue) transcatheter mitral valve edge-to-edge repair (M-TEER) systems. The composite endpoint includes all-cause mortality and heart failure (HF) rehospitalization. Abbreviations as in Figure 1.

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  Figure 3. NYHA Functional Class at Follow-Up Bar graphs comparing NYHA functional class at 1 month and 1 year. The progressively darker shades of yellow correlate with increasing grades of NYHA functional class from I to IV. Abbreviations as in Figure 1.

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  Central Illustration. Early- vs Newer-Generation M-TEER System in the OCEAN-Mitral Registry Illustration showing that the newer-generation transcatheter mitral valve edge-to-edge repair (M-TEER) system reduced procedural time and the number of clips required per procedure, achieving a lower transmitral mean pressure gradient (TMPG) and comparable mitral regurgitation (MR) reduction to the early-generation system. Residual MR (≥3+) was observed in 5.4% of the early-generation group and in 6.0% of the newer-generation group in the degenerative mitral regurgitation (DMR) cohort, whereas in 2.9% of the early-generation group and in 2.0% of the newer-generation group in the functional mitral regurgitation (FMR) cohort. The newer-generation device demonstrated a reduced risk of heart failure (HF) rehospitalization, with a more pronounced protective effect in patients with DMR than those with FMR. OCEAN-Mitral Registry = OCEAN (Optimized Catheter Valvular Intervention)-Mitral Registry.