Effect of Renal Impairment on Clinical Outcomes After Mitral Valve Transcatheter Edge-to-Edge Repair

Figures

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  Figure 1. Patient’s Flow The 2,150 patients undergoing mitral valve transcatheter edge-to-edge repair using MitraClip were categorized into 3 groups according to their renal function as follows: normal estimated glomerular filtration rate (eGFR) group: n = 291, 13.5%; renal impairment group: n = 1,746, 81.2%; and dialysis group: n = 113, 5.3%. The etiology of mitral regurgitation (MR) in each group was also noted.

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  Figure 2. Kaplan-Meier Analysis for the Endpoints Kaplan-Meier analysis revealed that patients with renal impairment and those on dialysis had a significantly higher incidence of major adverse cardiovascular event (MACE) (A), all-cause death (B), and heart failure (HF) hospitalization (C) than those with normal estimated glomerular filtration rate (eGFR). M-TEER = mitral valve transcatheter edge-to-edge repair.

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  Figure 3. Kaplan-Meier Analysis for MACE in FMR and DMR Comparison of functional mitral regurgitation (FMR) and degenerative mitral regurgitation (DMR). Patients on dialysis showed a higher incidence of MACE than those with normal eGFR and renal impairment in the FMR (A) and DMR (B) groups. Abbreviations as in Figure 2.

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  Central Illustration. The Prevalence and Outcomes of Renal Impairment in Mitral Valve Transcatheter Edge-to-Edge Repair Patients Baseline renal impairment was associated with an increased incidence of major adverse cardiovascular events (MACE) after mitral valve transcatheter edge-to-edge repair (M-TEER) for severe mitral regurgitation. Dialysis was the strongest predictor of MACE. eGFR = estimated glomerular filtration rate; HF = heart failure.