Symptomatic Peripheral Arterial Disease in Women
Key result
Baseline levels of sICAM-1 were independently associated with incident symptomatic peripheral arterial disease in women (adjusted HR for extreme tertiles 4.0; 95% CI 1.9-8.6).
Why the study?
Do baseline levels of novel biomarkers predict incident symptomatic peripheral arterial disease in women without prior vascular disease?
Population
27,935 US female health professionals ≥ 45 years of age without diagnosed vascular disease at baseline
Design
Cohort
Follow-up
median 12.3 years
Authors
Discussion
Loading...
Member takes
Implication
sICAM-1 may aid PAD risk stratification in women; hypothesis-generating and requires validation before clinical adoption.
Study Design
Type
Cohort (n=27,935)
Structured PICO
Do baseline levels of novel biomarkers predict incident symptomatic peripheral arterial disease in women without prior vascular disease?
P
Population
27,935 US female health professionals ≥ 45 years of age without diagnosed vascular disease at baseline
I
Intervention
Assessment of baseline biomarkers including high-sensitivity C-reactive protein, fibrinogen, soluble intercellular adhesion molecule-1 (sICAM-1), homocysteine, lipoprotein(a), hemoglobin A1c, creatinine, and conventional lipid levels
O
Outcome
Confirmed incident symptomatic peripheral arterial disease (PAD)hard clinical
Main Result
Effect estimate: HR 4.0 (95% CI 1.9-8.6)
Elevated levels of sICAM-1, hs-CRP, and TC:HDL-C, along with lower HDL-C, are independent predictors of incident symptomatic peripheral arterial disease in initially healthy women.
Cite This Study
Pradhan et al. (2008) conducted a cohort in Peripheral arterial disease (PAD) (n=27,935). Novel biomarkers (including sICAM-1 and hs-CRP) vs. Lowest tertile was evaluated on Incident symptomatic peripheral arterial disease (HR 4.0, 95% CI 1.9-8.6). Baseline levels of sICAM-1 were independently associated with incident symptomatic peripheral arterial disease in women (adjusted HR for extreme tertiles 4.0; 95% CI 1.9-8.6).