Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 11, 2013American Journal of HypertensionOpen Access

Associations of Candidate Biomarkers of Vascular Disease with the Ankle-Brachial Index and Peripheral Arterial Disease

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Are circulating levels of candidate biomarkers associated with the ankle-brachial index and peripheral arterial disease in African-Americans and non-Hispanic whites?

Population

2,443 individuals belonging to hypertensive sibships, comprising 1,291 African-Americans and 1,152…

Design

Cross-sectional

Authors

ZYZ. YeZAZ. AliGKGeorge G. KleeUniversity of Southern California

Discussion

Loading...

Member takes

Implication

Biomarker associations with ABI and PAD appear stronger in African-Americans; leaves open predictive utility and generalizability pending prospective validation.

Structured PICO

Are circulating levels of candidate biomarkers associated with the ankle-brachial index and peripheral arterial disease in African-Americans and non-Hispanic whites?

P
Population
2,443 individuals belonging to hypertensive sibships, comprising 1,291 African-Americans (71.1% women, mean age 63.4±9.3 years) and 1,152 non-Hispanic whites (57.5% women, mean age 58.5±10.1 years).
I
Intervention
Circulating levels of 47 candidate biomarkers
O
Outcome
Ankle-brachial index (ABI) and presence of peripheral arterial disease (PAD, defined as ABI ≤ 0.90)surrogate

A multimarker approach improves the prediction of interindividual variation in ABI and the presence of PAD, particularly in African-Americans.

Cite This Study

Ye et al. (2013) studied this question.

synapsesocial.com/papers/6a836a71eaaeb88ca9c51b2ehttps://doi.org/10.1093/ajh/hps073
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Biomarkers Associated With Pulse Pressure in African-Americans and Non-Hispanic Whites2011 · 24 citations
  2. 2Mid-Regional Pro-Adrenomedullin Is Associated With Pulse Pressure, Left Ventricular Mass, and Albuminuria in African Americans With Hypertension2009 · 15 citations
  3. 3Evaluation of Multiple Biomarkers of Cardiovascular Stress for Risk Prediction and Guiding Medical Therapy in Patients With Stable Coronary Disease2011 · 143 citations
  4. 4Impaired Recovery of Blood Flow After Hind-Limb Ischemia in Mice Lacking Guanylyl Cyclase-A, a Receptor for Atrial and Brain Natriuretic Peptides2009 · 46 citations
  5. 5Association of Plasma Resistin With Glomerular Filtration Rate and Albuminuria in Hypertensive Adults2007 · 103 citations