Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 16, 2013Journal of the Renin-Angiotensin-Aldosterone SystemOpen Access

A study on the polymorphisms of the renin–angiotensin system pathway genes for their effect on blood pressure levels in males from Algeria

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Do AGT M235T, AT1R +1166A/C, and ACE I/D polymorphisms affect systolic, diastolic, and pulse pressure values in Algerian males free of CHD?

Population

115 male subjects from Algeria, free of coronary heart disease (CHD)

Comparison

Presence of AGT M235T, AT1R +1166A/C, and ACE… vs Different alleles/genotypes within the same…

Design

Cross-sectional

Authors

DMDjabaria Naïma MeroufelUniversité des Sciences et de la Technologie d'Oran Mohamed BoudiafSMSounnia Médiène-BenchekorUniversité Oran 1 Ahmed Ben BellaJDJulie DumontInserm

Discussion

Loading...

Member takes

Implication

Null findings advise against genotyping these variants for BP prediction in Algerian males; leaves open ancestry-specific effects in larger cohorts.

Structured PICO

Do AGT M235T, AT1R +1166A/C, and ACE I/D polymorphisms affect systolic, diastolic, and pulse pressure values in Algerian males free of CHD?

P
Population
115 male subjects from Algeria, free of coronary heart disease (CHD)
I
Intervention
Presence of AGT M235T, AT1R +1166A/C, and ACE I/D polymorphisms
C
Comparator
Different alleles/genotypes within the same polymorphisms (e.g., ACE DD subjects)
O
Outcome
Variations in systolic (SBP), diastolic (DBP) and pulse pressure (PP) valuessurrogate

In a small sample of Algerian males, common renin-angiotensin system gene polymorphisms were not significantly associated with blood pressure variations.

Limitations

  • small sample size

Cite This Study

Meroufel et al. (2013) studied this question.

synapsesocial.com/papers/6a0ee194b7cc3b883f22d8d8https://doi.org/10.1177/1470320313485898
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association of angiotensin II type 1 receptor gene polymorphism with essential hypertension1997 · 168 citations
  2. 2Association of ACE I/D polymorphism in Tunisian patients with dilated cardiomyopathy2010 · 21 citations
  3. 3Angiotensin II Type 1 Receptor Gene Polymorphism Is Associated With Increase of Left Ventricular Mass But Not With Hypertension1998 · 127 citations
  4. 4Population-Based Case-Control Study of Renin-Angiotensin System Genes Polymorphisms and Hypertension among Hispanics2008 · 48 citations
  5. 5Association between Angiotensin I-Converting Enzyme Gene Polymorphism and Hypertension in Selected Individuals of the Bangladeshi Population2002 · 56 citations