April 20, 2023Revista Portuguesa de CardiologiaOpen Access

Treatment with gentamicin-impregnated collagen sponges in reducing infection of implantable cardiac devices: 10-year analysis with propensity score matching

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Why the study?

Device infection is increasing and linked to higher mortality in CIED patients, but evidence regarding the effectiveness of gentamicin-impregnated collagen sponges in CIED procedures was lacking.

Does the addition of gentamicin-impregnated collagen sponges to routine antibiotic prophylaxis reduce CIED infection in adult patients undergoing CIED implantation?

Structured PICO

Does the addition of gentamicin-impregnated collagen sponges to routine antibiotic prophylaxis reduce CIED infection in adult patients undergoing CIED implantation?

Population

2,986 adult patients (mean age 72.8, 71.3% male) who received cardiac implantable electronic devices (CIEDs) between 2010 and 2020. Inclusion criteria: age >18 years, completion of one-year follow-up, absence of active infection or active inflammatory disease, and NYHA functional class I-III.

Intervention

Gentamicin-impregnated collagen sponges (GICSs) added to routine periprocedural systemic antibiotic prophylaxis.

Comparator

Routine periprocedural systemic antibiotic prophylaxis alone (intravenous administration of first-generation cephalosporins such as cefazolin or flucloxacillin, or vancomycin in case of allergy).

Outcome

CIED infection rate at one year.safety

The use of gentamicin-impregnated collagen sponges during CIED implantation is associated with a significant reduction in device infections at one year.

Limitations

Observational nature of the study
Single university hospital center population
Predictors of infection risk may vary worldwide

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May support GICS addition to lower CIED infections; leaves open need for RCTs before practice change.

Cite This Study

Matteucci et al. (2023) studied this question.

synapsesocial.com/papers/6a0ee1dae29b511e9f2293d9 https://doi.org/10.1016/j.repc.2023.01.023

Topics

Cardiac device therapy

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Treatment with gentamicin-impregnated collagen sponges in reducing infection of implantable cardiac devices: 10-year analysis with propensity score matching

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Topics

Treatment with gentamicin-impregnated collagen sponges in reducing infection of implantable cardiac devices: 10-year analysis with propensity score matching

Structured PICO

Limitations

Discussion

Implication

Cite This Study

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Topics

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