What question did this study set out to answer?

To evaluate the effectiveness of systemic antibiotic prophylaxis in reducing postoperative infection rates in patients undergoing permanent pacemaker implantation.

May 12, 1998CirculationOpen Access

Antibiotic Prophylaxis for Permanent Pacemaker Implantation

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Why the study?

Does systemic antibiotic prophylaxis reduce infection rates in patients undergoing permanent pacemaker implantation?

Population

2023 patients with established permanent pacemaker implantation across 7 randomized trials

Comparison

Systemic antibiotic prophylaxis at the time of… vs Control group (no systemic antibiotic prophylaxis)

Design

Meta-analysis, Included trials were randomized, Included open or blind trials

Authors

ACAntoine Da CostaElectrophysiology GKGilbert KirkorianUniversité Claude Bernard Lyon 1 MCMichel CucheratUniversité Claude Bernard Lyon 1

Discussion

Member takes

Implication

Supports routine antibiotic prophylaxis before permanent pacemaker implantation; confirms benefit in Level 1 evidence.

Key Points

To evaluate the effectiveness of systemic antibiotic prophylaxis in reducing postoperative infection rates in patients undergoing permanent pacemaker implantation.
Conducted a meta-analysis searching Medline, Embase, Current Contents, and bibliographies for prospective, randomized, open or blind controlled trials comparing systemic antibiotics to a control group.
Included 7 randomized controlled trials with a total of 2,023 patients undergoing new permanent pacemaker implants or replacements.
Tracked end point events encompassing wound infection, pocket abscess, purulent secretion, septicemia, right infective endocarditis, septic pulmonary embolism, or repeat operation for infection.
The incidence of infective end point events across control groups ranged from 0% to 12%.
Systemic antibiotic prophylaxis significantly reduced the risk of infective complications compared with control (common OR 0.256, 95% CI 0.10 to 0.656, P=0.0046).

Structured PICO

Does systemic antibiotic prophylaxis reduce infection rates in patients undergoing permanent pacemaker implantation?

Population

2023 patients with established permanent pacemaker implantation (new implants or replacements) across 7 randomized trials

Intervention

Systemic antibiotic prophylaxis at the time of pacemaker insertion

Comparator

Control group (no systemic antibiotic prophylaxis)

Outcome

Any infection after pacemaker implantation (wound infection, septicemia, pocket abscess, purulent secretion, right infective endocarditis, inflammatory signs, a positive culture, septic pulmonary embolism, or repeat operation for an infective complication)safety

Systemic antibiotic prophylaxis significantly reduces the incidence of potentially serious infective complications after permanent pacemaker implantation.

Cite This Study

Costa et al. (1998) studied this question.

synapsesocial.com/papers/6a0ee1dbe29b511e9f2293ea https://doi.org/10.1161/01.cir.97.18.1796

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Antibiotic Prophylaxis for Permanent Pacemaker Implantation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Antibiotic Prophylaxis for Permanent Pacemaker Implantation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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