Why the study?
Does prophylactic antibiotic treatment prevent pacemaker pocket infection in patients requiring elective permanent pacemaker implantation or generator replacement?
Population
500 patients requiring elective permanent pacemaker implantation or generator replacement
Comparison
Prophylactic antibiotic treatment at the time of… vs No prophylactic antibiotics
Design
RCT, prospectively randomized
Follow-up
12 months
Authors
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Prophylactic antibiotics do not reduce pocket infection risk; challenges routine use and supports skin-preparation-focused protocols in future trials.
Does prophylactic antibiotic treatment prevent pacemaker pocket infection in patients requiring elective permanent pacemaker implantation or generator replacement?
Prophylactic antibiotic treatment during pacemaker implantation does not significantly reduce the risk of pocket infection when careful preoperative skin preparation is performed.
Ramsdale et al. (1984) studied this question.
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