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April 24, 1976BMJOpen Access

Prognosis of new and worsening angina pectoris.

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Why the study?

What is the natural history and prognosis of new and worsening angina pectoris in men under 70 years of age?

Population

251 men aged under 70 years with new and worsening angina pectoris, referred by selected general…

Design

Cohort

Follow-up

6 months

Authors

BDB.M. DuncanLiverpool John Moores UniversityMFMary FultonDavidson CollegeSMS L MorrisonIcahn School of Medicine at Mount Sinai

Discussion

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Implication

Early MI risk in new angina supports close initial surveillance; leaves open whether contemporary therapies alter this prognosis.

Key Points

  • To examine the natural history, risk of serious complications, and predictive clinical indicators in patients presenting with new or worsening angina pectoris.
  • Followed a cohort of 251 ambulatory men under 70 years of age referred by general practitioners to a hospital clinic over 2.5 years.
  • Assessed clinical outcomes at six months and performed discriminant function analysis across multiple variables to identify predictors of serious cardiac complications.
  • Myocardial infarction occurred in 39 of 251 patients (15.5%), resulting in nine deaths, with 72% of these events occurring within six weeks of onset or worsening.
  • Among 212 patients without infarction reviewed at six months, 66 were pain-free for three months, and 81% of 128 previously employed men under 65 returned to full-time work.
  • An increased cardiothoracic ratio was the only statistically significant predictor of serious cardiac complications.

Structured PICO

What is the natural history and prognosis of new and worsening angina pectoris in men under 70 years of age?

P
Population
251 men aged under 70 years with new and worsening angina pectoris, referred by selected general practitioners to a special hospital clinic over two and a half years.
O
Outcome
Development of heart attacks (myocardial infarction) and deathhard clinical

Cite This Study

Duncan et al. (1976) studied this question.

synapsesocial.com/papers/6a0ee3852eca052da647e375https://doi.org/10.1136/bmj.1.6016.981
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Incidence, clinical characteristics, and short-term prognosis of angina pectoris.1995 · 108 citations
  2. 2Clinical Course and Symptomatology of Angina Pectoris in a Population Study1986 · 16 citations
  3. 3The prognosis for patients with new-onset angina who have undergone cardiac catheterization.1983 · 66 citations
  4. 4Angina Pectoris in Men1973 · 99 citations
  5. 5Five year prognosis in patients with angina identified in primary care: incident cohort study2009 · 51 citations