Why the study?
Does angiotensin II activate StAR transcription and steroidogenesis via JAK2 and calcium signaling in human adrenocortical cells?
Population
H295R human adrenocortical cells
Comparison
Angiotensin II treatment and AG490 treatment vs K+ treatment or untreated cells
Design
Preclinical
Authors
Loading...
Caution against clinical extrapolation from animal data; leaves open JAK2's role in human adrenal steroidogenesis.
Does angiotensin II activate StAR transcription and steroidogenesis via JAK2 and calcium signaling in human adrenocortical cells?
Angiotensin II stimulates StAR expression and steroidogenesis in adrenocortical cells via a novel pathway requiring JAK2 activation and calcium influx.
Li et al. (2003) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: