Why the study?
Does Thapsigargin increase cytoplasmic Ca2+ concentration and aldosterone production in isolated rat adrenal glomerulosa cells?
Population
Isolated rat adrenal glomerulosa cells
Comparison
Thapsigargin, alone or in combination with… vs Baseline or control conditions (implied)
Design
Preclinical
Authors
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Thapsigargin effects in rat cells should not alter clinical aldosterone management; leaves open calcium store depletion as a modulator of potassium-stimulated secretion.
Does Thapsigargin increase cytoplasmic Ca2+ concentration and aldosterone production in isolated rat adrenal glomerulosa cells?
Thapsigargin increases cytoplasmic Ca2+ and aldosterone production in rat adrenal glomerulosa cells and potentiates the effects of potassium, suggesting that intracellular Ca2+ depletion enhances cellular response to depolarization.
Hajnóczky et al. (1991) studied this question.
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