Population
Isolated glomerulosa cells prepared from bovine adrenal glands
Comparison
Angiotensin II, potassium, divalent ionophore… vs Basal conditions or varying calcium concentrations
Design
Preclinical
Authors
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Hypothesis-generating in animal glomerulosa cells; leaves open whether calcium channel blockade modulates aldosterone in humans.
This preclinical study demonstrates that calcium influx is a crucial secondary messenger for angiotensin II- and potassium-stimulated aldosterone production in adrenal glomerulosa cells.
Foster et al. (1981) studied this question.
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