Key result
The sustained phase of angiotensin II-mediated aldosterone secretion depends on both an initial transient rise in cytosolic calcium and a continued high rate of calcium influx.
Population
Adrenal glomerulosa cells
Design
Preclinical
Authors
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No immediate clinical implications for RAAS modulation; leaves open sustained calcium influx as a mechanistic research target.
The sustained phase of angiotensin II-mediated aldosterone secretion in adrenal glomerulosa cells requires continuous calcium influx to regulate activated C-kinase turnover.
Kojima et al. (1985) studied Adrenal glomerulosa cells (in vitro). Angiotensin II and various calcium modulators (dantrolene, A23187, OAG, BAY K 8644, nitrendipine) was evaluated on Aldosterone secretion. The sustained phase of angiotensin II-mediated aldosterone secretion depends on both an initial transient rise in cytosolic calcium and a continued high rate of calcium influx.
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