What does this research mean for the field?

Angiotensin II, potassium (K+), and ACTH stimulate calcium influx in adrenal glomerulosa cells via a common calcium channel, though they act through different mechanisms to alter its function. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 1, 1985Journal of Biological ChemistryOpen Access

Characteristics of angiotensin II-, K+- and ACTH-induced calcium influx in adrenal glomerulosa cells. Evidence that angiotensin II, K+, and ACTH may open a common calcium channel.

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Population

Isolated adrenal glomerulosa cells

Comparison

Angiotensin II (1 nM), K+, and ACTH (1 nM) vs Basal conditions

Design

Preclinical

Authors

IKIkuho KojimaTohoku University KKKensuke KojimaKyoto University HRH RasmussenElectrophysiology

Discussion

Member takes

Implication

Convergence on a shared calcium channel in glomerulosa cells; hypothesis-generating for aldosterone regulation and leaves open human translation.

Structured PICO

Population

Isolated adrenal glomerulosa cells

Intervention

Angiotensin II (1 nM), K+, and ACTH (1 nM)

Comparator

Basal conditions

Outcome

Calcium influx ratesurrogate

Angiotensin II, K+, and ACTH stimulate calcium influx in adrenal glomerulosa cells via a common calcium channel but act by different mechanisms.

Cite This Study

Kojima et al. (1985) studied this question.

synapsesocial.com/papers/6a156b42814bf8ec9a4e9076 https://doi.org/10.1016/s0021-9258(17)39348-1

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Implication

Convergence on a shared calcium channel in glomerulosa cells; hypothesis-generating for aldosterone regulation and leaves open human translation.

Characteristics of angiotensin II-, K+- and ACTH-induced calcium influx in adrenal glomerulosa cells. Evidence that angiotensin II, K+, and ACTH may open a common calcium channel.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characteristics of angiotensin II-, K+- and ACTH-induced calcium influx in adrenal glomerulosa cells. Evidence that angiotensin II, K+, and ACTH may open a common calcium channel.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider