Key result
Angiotensin II and extracellular potassium induce rapid rises in cytosolic free calcium in bovine adrenal glomerulosa cells, triggering aldosterone secretion via distinct mechanisms.
Population
Intact bovine adrenal glomerulosa cells loaded with the fluorescent calcium indicator quin 2
Design
Preclinical
Authors
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Highlights distinct calcium-dependent aldosterone pathways in adrenal cells; leaves open translation to human hypertension or therapy.
Angiotensin II and extracellular potassium trigger aldosterone secretion in bovine adrenal glomerulosa cells by inducing rapid rises in cytosolic free calcium through distinct mechanisms (receptor-mediated vs. voltage-dependent calcium channels).
Capponi et al. (1984) studied In vitro study of bovine adrenal glomerulosa cells. Angiotensin II and extracellular potassium was evaluated on Changes in cytosolic free calcium ([Ca2+]i), membrane potential, and aldosterone production. Angiotensin II and extracellular potassium induce rapid rises in cytosolic free calcium in bovine adrenal glomerulosa cells, triggering aldosterone secretion via distinct mechanisms.