Population
Bovine adrenal zona glomerulosa cells
Design
Preclinical
Authors
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Thapsigargin's dual Ca2+ actions in adrenal cells warrant dose-specific experimental caution; leaves open aldosterone-related cardiovascular research applications.
Thapsigargin has a dual, concentration-dependent effect on adrenal glomerulosa cells, acting as a Ca2+ store depleter at low doses and a voltage-activated Ca2+ channel blocker at high doses.
Rossier et al. (1993) studied this question.
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