Key result
Proposed four-stage HFpEF classification categorizes patients by sequential chamber involvement to guide prognosis and therapy.
Why the study?
HFpEF management remains largely unresolved due to limited mechanistic understanding and challenges phenotyping this heterogeneous syndrome, requiring a paradigm shift to personalise care and unify approaches for future clinical trials.
Proposes a novel echocardiography-based staging classification for HFpEF to personalize care and unify approaches for future clinical trials.
Answers are grounded in this paper and cite their sources.
May support HFpEF phenotyping by chamber involvement; leaves open validation before guiding practice or trials.
The management of heart failure with preserved ejection fraction (HFpEF) remains largely unresolved due to our limited understanding of the underlying mechanisms of the pathology and the challenges in accurately phenotyping this heterogeneous syndrome. A paradigm shift is required to personalise care and unify our approaches to HFpEF patients for future clinical trials. Accordingly, we propose a staging classification for HFpEF based on the identification of the involved cardiac chambers by echocardiography.
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Shchendrygina et al. (2024) conducted a review in Heart failure with preserved ejection fraction (HFpEF). Echocardiographic staging classification was evaluated. A proposed four-stage classification system for heart failure with preserved ejection fraction categorizes patients based on sequential cardiac chamber involvement to guide prognosis and therapies.
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