Key result
Acute MI in young patients linked to markedly higher five-year mortality than matched controls.
Why the study?
Acute myocardial infarction causes significant loss-of-life expectancy, especially in younger females, making the description of sex-stratified trends in risk factors and clinical outcomes crucial for optimizing prevention strategies.
What are the trends in risk factors and clinical outcomes among young patients with acute myocardial infarction, stratified by sex?
Population
44 254 AMI cases aged 18-59 and 220 721 matched non-AMI controls in Sweden
Comparison
Young AMI cases vs matched non-AMI general population controls, stratified by sex
Design
Nationwide registry-based cohort study
Authors
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Elevated long-term mortality after young AMI; leaves open whether sex-specific risk factor modification improves outcomes.
Cohort (n=264,975)
Yes
What are the trends in risk factors and clinical outcomes among young patients with acute myocardial infarction, stratified by sex?
Absolute Event Rate: 6.1% vs 1.3%
Young female AMI patients have a higher risk factor burden and worse clinical outcomes compared to young male AMI patients, highlighting the need for enhanced, sex-specific prevention and follow-up strategies.
Simonsson et al. (2025) conducted a cohort in Acute myocardial infarction (AMI) (n=264,975). Acute myocardial infarction vs. Matched non-AMI controls was evaluated on Five-year mortality (females). Acute myocardial infarction in young patients was associated with higher 5-year mortality than matched controls (6.1% vs 1.3% in females; 4.9% vs 1.8% in males), alongside a high risk factor burden.
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