Key result
Young survivors of AMI had higher 4-year mortality than the general population, with standardized mortality ratios in the most recent period ranging from 2.43 in older men to 13.53 in younger women.
Cohort (n=37,276)
Yes
Young female survivors of AMI have a significantly higher relative risk of long-term mortality compared to the general population than their male counterparts, with trends worsening in recent years.
Young female AMI survivors face highest excess mortality; hypothesis-generating for sex-specific secondary prevention trials.
OBJECTIVE: To examine sex-specific trends in 4-year mortality among young patients with first acute myocardial infarction (AMI), 1987-2006. DESIGN: Prospective cohort study. SETTING: Sweden. PARTICIPANTS: We identified 37 276 cases (19.4% women; age, 25-54 years) from the Swedish Inpatient Register, 1987-2006, who had survived 28 days after an AMI. OUTCOME MEASURES: 4-year mortality from all causes and standard mortality ratio (SMR). RESULTS: From the first to last 5-year period, the absolute excess risk decreased from 1.38 to 0.50 and 1.53 to 0.59 per 100 person-years among men aged 25-44 and 45-54 years, respectively. Corresponding figures for women were a decrease from 2.26 to 1.17 and from 1.93 to 1.45 per 100 person-years, respectively. Trends for women were non-linear, decreasing to the same extent as those for men until the third period, then increasing. For the last 5-year period, the standardised mortality ratio for young survivors of AMI compared with the general population was 4.34 (95% CI 3.04 to 5.87) and 2.43 (95% CI 2.12 to 2.76) for men aged 25-44 and 45-54 years, respectively, and 13.53 (95% CI 8.36 to 19.93) and 6.42 (95% CI 5.24 to 7.73) for women, respectively. Deaths not associated with cardiovascular causes increased from 21.5% to 44.6% in men and 41.5% to 65.9% in women. CONCLUSIONS: Young male survivors of AMI have low absolute long-term mortality rates, but these rates remain twofold to fourfold that of the general population. After favourable development until 2001, women now have higher absolute mortality than men and a 6-fold to 14-fold risk of death compared with women in the general population.
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Nielsen et al. (2014) conducted a cohort in First acute myocardial infarction (AMI) (n=37,276). First acute myocardial infarction before age 55 vs. General population was evaluated on 4-year mortality from all causes and standard mortality ratio (SMR). Young survivors of AMI had higher 4-year mortality than the general population, with standardized mortality ratios in the most recent period ranging from 2.43 in older men to 13.53 in younger women.
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