Ankle-Brachial Index and 7-Year Ischemic Stroke Incidence
Key result
Low ankle-brachial index (<0.80) was associated with increased ischemic stroke incidence, but the relationship was not significant after adjusting for major risk factors (HR 1.93; 95% CI 0.78-4.78).
Why the study?
Does low ankle-brachial index predict incident ischemic stroke in adults aged 45 to 64 years?
Population
14,839 black and white men and women aged 45 to 64 years
Comparison
Low ankle-brachial index (ABI <0.80) vs Higher categories of ankle-brachial index
Design
Cohort
Follow-up
approximately 7 years
Authors
Discussion
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Member takes
Implication
Low ABI is not independently associated with incident stroke; leaves open its incremental value beyond conventional risk factors.
Study Design
Type
Cohort (n=14,839)
Multicenter
Yes
Structured PICO
Does low ankle-brachial index predict incident ischemic stroke in adults aged 45 to 64 years?
P
Population
14,839 black and white men and women aged 45 to 64 years
I
Intervention
Low ankle-brachial index (ABI <0.80)
C
Comparator
Higher categories of ankle-brachial index
O
Outcome
Incident ischemic strokehard clinical
Main Result
Effect estimate: HR 1.93 (95% CI 0.78 to 4.78)
p-value: p=0.03
Low ABI is associated with increased incidence of ischemic stroke, but this relationship is substantially attenuated after adjusting for major cardiovascular risk factors.
Cite This Study
Tsai et al. (2001) conducted a cohort in Ischemic stroke (n=14,839). Low ankle-brachial index (ABI <0.80) vs. Higher ankle-brachial index was evaluated on Incident ischemic stroke (HR 1.93, 95% CI 0.78 to 4.78, p=0.03). Low ankle-brachial index (<0.80) was associated with increased ischemic stroke incidence, but the relationship was not significant after adjusting for major risk factors (HR 1.93; 95% CI 0.78-4.78).