Study of the Aetiology of Carcinoma of the Lung
Key result
A total burden score combining carotid intima-media thickness and the number of segments with plaque improved 5-year ICVD risk prediction compared with conventional risk scores (NRI +17.1%).
Why the study?
Does a total burden score (TBS) of carotid atherosclerosis improve the prediction of ischaemic cardiovascular disease events compared to conventional risk scores in a Chinese cohort?
Population
1734 Chinese subjects (623 men, 1111 women) aged 43–79 years at baseline.
Comparison
Total burden score of carotid atherosclerosis vs Conventional risk score, IMT alone, or number of…
Design
Cohort
Follow-up
5 years
Authors
Discussion
Loading...
Member takes
Implication
May refine ICVD risk stratification in Chinese adults; extends conventional scores but remains hypothesis-generating pending validation.
Study Design
Type
Observational (n=1,734)
Structured PICO
Does a total burden score (TBS) of carotid atherosclerosis improve the prediction of ischaemic cardiovascular disease events compared to conventional risk scores in a Chinese cohort?
P
Population
1734 Chinese subjects (623 men, 1111 women) aged 43–79 years at baseline.
I
Intervention
Total burden score (TBS) of carotid atherosclerosis (combining carotid IMT and number of segments with plaque)
C
Comparator
Conventional risk score, IMT alone, or number of segments with plaque alone
O
Outcome
Ischaemic cardiovascular disease (ICVD) events, including coronary heart disease and ischaemic strokecomposite
A novel total burden score combining carotid IMT and plaque segments significantly improves the 5-year risk prediction of ischaemic cardiovascular disease over conventional risk scores.
Cite This Study
Doll et al. (1952) conducted an observational in Carotid atherosclerosis (n=1,734). Total burden score (TBS) of carotid atherosclerosis vs. Conventional risk score was evaluated on Ischaemic cardiovascular disease (ICVD) events, including coronary heart disease and ischaemic stroke. A total burden score combining carotid intima-media thickness and the number of segments with plaque improved 5-year ICVD risk prediction compared with conventional risk scores (NRI +17.1%).