Key result
Serum sICAM-1 predicts early atherosclerosis in obese subjects with ~96% sensitivity.
Why the study?
Endothelial dysfunction drives atherosclerosis in obesity, prompting evaluation of specific endothelial dysfunction biomarkers as sensitive indices for early prediction of atherosclerosis in obese subjects.
Are serum adhesion molecules and inflammatory markers sensitive biomarkers for early prediction of atherosclerosis in obese male subjects?
Observational (n=150)
No
Are serum adhesion molecules and inflammatory markers sensitive biomarkers for early prediction of atherosclerosis in obese male subjects?
Effect estimate: AUC 0.93
p-value: p=<0.001
Serum adhesion molecules and inflammatory markers demonstrate high sensitivity for predicting early atherosclerosis in obese male subjects.
May support biomarker research in obese males; hypothesis-generating and should not yet change practice.
Background: The obesity increased incidence of diabetes, hypertension and atherosclerosis and rate of morbidity and mortality. The main cause of atherosclerosis is endothelial dysfunction and formation of foam cells and macrophage that lead to unfavorable complications. This study evaluated specific biomarkers for endothelial dysfunction as sensitive indices for early predication of atherosclerosis in obese subjects. Study Design: One hundred fifty male age and sex matching were included in the current study divided into three groups according to body mass index (BMI): Control (BMI ≤ 22), obese (BMI> 28) and obese with atherosclerosis (BMI> 28). Fasting serum was subjected for determination of adhesion molecules, sICAM-1, sVCAM-1, E-selectin, oxo-LDL and 8-iso-PGF2α by ELISA technique. Results: Data obtained showed that, a significant elevation of serum inflammatory markers CRP, IL-6 and TNF-α and adhesion molecules sICAM-1 (p<0.001) with sensitivity 96%, sVCAM-1 (p <0.01) with sensitivity 92%, E-selectin (p<0.001) with sensitivity 94%, oxo-LDL (p <0.05) and 8-iso-PGF2α (p < 0.001) with sensitivity 97% in obese with atherosclerosis compared with obese and control. Conclusion: The levels of serum adhesion molecules contributed in the pathogenesis of endothelial dysfunction can be used as sensitive biomarkers for early prediction of atherosclerosis in obese subjects.
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Abulnaja et al. (2022) conducted an observational in Obesity and atherosclerosis (n=150). Biomarker evaluation (sICAM-1, sVCAM-1, E-selectin, oxo-LDL, 8-iso-PGF2α) vs. Normal non-obese and obese without atherosclerosis was evaluated on Diagnostic accuracy (sensitivity and specificity) of sICAM-1 for atherosclerosis in obese subjects (AUC 0.93, p=<0.001). Serum adhesion molecules, particularly sICAM-1 (AUC 0.93, 96% sensitivity) and 8-iso-PGF2α (AUC 0.90, 97% sensitivity), are highly sensitive and specific biomarkers for early prediction of atherosclerosis in obese subjects.
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