Plasma lipoproteins in familial combined hyperlipidemia and monogenic familial hypertriglyceridemia
Population
Subjects with familial combined hyperlipidemia, monogenic familial hypertriglyceridemia, and normal control…
Design
Cross-sectional
Authors
Discussion
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Implication
Supports distinct entities in hypertriglyceridemia subtypes; leaves open effects on risk stratification or therapy.
Key Points
- To evaluate and compare plasma lipoprotein concentration, particle size, and apoprotein composition between two common inherited forms of hypertriglyceridemia and healthy controls.
- Assessed lipoprotein composition, concentration, and particle diameter in individuals with familial hypertriglyceridemia, familial combined hyperlipidemia, and normal controls.
- Measured triglyceride-to-apoprotein B ratios, apoprotein A-I and A-II levels, and evaluated interrelationships among VLDL, LDL, and HDL subfractions.
- Familial hypertriglyceridemia displayed triglyceride-enriched VLDL (TG/apoB ratio 25.7 ± 8.9 vs. 9.6 ± 12.2 in controls, P < 0.001) with larger particle diameters (3.27 ± 0.28 pm vs. 2.87 ± 0.16 pm in FCHL, P < 0.02).
- Familial combined hyperlipidemia showed smaller VLDL particles (P < 0.05), a reduced apoA-I/apoA-II ratio (P < 0.01), and a strong reciprocal relationship between VLDL and LDL concentrations (r = -0.80 to -0.87).
- In familial hypertriglyceridemia, HDL cholesterol was decreased by 33% and HDL triglycerides increased by 46%, with VLDL triglycerides inversely correlating with HDL cholesterol (r = -0.74, P < 0.005).
Structured PICO
P
Population
Subjects with familial combined hyperlipidemia, monogenic familial hypertriglyceridemia, and normal control subjects
C
Comparator
Normal subjects
O
Outcome
Plasma lipoprotein concentration, composition, and sizesurrogate
Familial combined hyperlipidemia and monogenic familial hypertriglyceridemia exhibit distinct lipoprotein composition and size profiles, supporting that they are distinct pathological entities.
Cite This Study
Brunzell et al. (1983) studied this question.