July 1, 1986Arteriosclerosis An Official Journal of the American Heart Association IncOpen Access

Plasma lipoproteins, apolipoproteins, and triglyceride metabolism in familial hypertriglyceridemia.

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Population

38 men with primary hypertriglyceridemia, comprising 17 with familial combined hyperlipidemia, 7 with…

Design

Cross-sectional

Authors

ASA.F.H. StalenhoefLeiden University PDPierre N.M. DemackerRoche (Switzerland)JLJ. A. LuttermanRadboud University Nijmegen

Discussion

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Implication

These apolipoprotein shifts may identify higher-risk FCH phenotypes; leaves open causal links to outcomes in longitudinal cohorts.

Structured PICO

Population

38 men with primary hypertriglyceridemia (phenotype IV), comprising 17 with familial combined hyperlipidemia (FCH), 7 with familial hypertriglyceridemia (FHT), and 14 with unclassified hypertriglyceridemia (UNC).

Comparator

Normal controls

Outcome

Parameters of lipoprotein metabolism including HDL cholesterol, apolipoproteins A-I, A-II, and B, LDL cholesterol, lipase activity, and triglyceride turnover ratesurrogate

Familial combined hyperlipidemia and familial hypertriglyceridemia share increased triglyceride overproduction and decreased HDL, but FCH is distinguished by higher LDL cholesterol and LDL/HDL ratio, potentially explaining higher cardiovascular risk.

Cite This Study

Stalenhoef et al. (1986) studied this question.

synapsesocial.com/papers/6a7078d535aa2c282ce1cb25 https://doi.org/10.1161/01.atv.6.4.387

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Plasma lipoproteins, apolipoproteins, and triglyceride metabolism in familial hypertriglyceridemia.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Plasma lipoproteins, apolipoproteins, and triglyceride metabolism in familial hypertriglyceridemia.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider