Key result
The presence of a posterolateral left ventricular scar independently predicted cardiovascular death or heart failure hospitalization following CRT (HR 3.06; 95% CI 1.63-7.7; P<0.0001).
Why the study?
Does the presence of a posterolateral left ventricular scar predict mortality and morbidity in heart failure patients following cardiac resynchronization therapy?
Population
62 patients with heart failure undergoing cardiac resynchronization therapy, mean age 67.3, 45 males.
Comparison
Presence of posterolateral left ventricular scar… vs Absence of PL scar (non-PL scars)
Design
Cohort
Follow-up
mean 741 days (range 75-1602 days)
Authors
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May warrant pre-CRT scar imaging to identify high-risk patients; leaves open whether scar-guided lead placement improves outcomes.
Cohort (n=62)
Does the presence of a posterolateral left ventricular scar predict mortality and morbidity in heart failure patients following cardiac resynchronization therapy?
Effect estimate: HR 3.06 (95% CI 1.63-7.7)
p-value: p=<0.0001
The presence of a posterolateral left ventricular scar, particularly if transmural, is associated with worse clinical outcomes and lower responder rates following cardiac resynchronization therapy.
Chalil et al. (2007) conducted a cohort in Heart failure (n=62). Posterolateral left ventricular scar vs. Absence of posterolateral scar was evaluated on Composite of cardiovascular death or hospitalization for worsening heart failure (HR 3.06, 95% CI 1.63-7.7, p=<0.0001). The presence of a posterolateral left ventricular scar independently predicted cardiovascular death or heart failure hospitalization following CRT (HR 3.06; 95% CI 1.63-7.7; P<0.0001).
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