Observational study demonstrates a skewed distribution of plasma Lp(a) lipoprotein independent of standard lipid levels in fasting adults, suggesting unique metabolic regulation.
The Lp(a) lipoprotein was purified from human plasma by ultracentrifugation and gel filtration on 6% agarose. It contained 27% protein, 65% lipid, and 8% carbohydrate. Quantification of the Lp(a) lipoprotein was performed by radial immunodiffusion. Both within‐assay and between‐assay coefficients of variation were inversely concentration dependent, decreasing from 20% and 27%, respectively, at 3 mg/100 ml to 7% and 12%, respectively, at concentrations above 8 mg/100 ml. The lower limit of sensitivity of the assay was 1.5 mg/100 ml. Of 340 unrelated fasting subjects tested, 81% had levels of the Lp(a) lipoprotein exceeding this lower limit. The distribution of Lp(a) concentrations in this population was skewed with a mean of 14 mg/100 ml and a median of 8 mg/100 ml. Lp(a) lipoprotein was not significantly correlated with age, sex, or cholesterol or glyceride concentrations.
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Albers et al. (1974) studied this question.
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