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May 25, 2022Clinical Kidney JournalOpen Access

Left ventricular dysfunction with preserved ejection fraction: the most common left ventricular disorder in chronic kidney disease patients

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Key result

SGLT2i improves outcomes in patients with HFpEF and CKD.

Why the study?

There is a need to translate knowledge of cardiac imaging abnormalities in CKD to clinical outcomes such as heart failure admission and premature cardiovascular death, especially regarding HFpEF.

Population

Patients with CKD and HFpEF

Design

Review

Authors

PMPatrick B. MarkHeart Failure & TransplantKMKenneth MangionCardiac ImagingARAlastair J. RankinUniversity of Glasgow

Discussion

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Implication

May support SGLT2 inhibitor consideration in HFpEF-CKD; leaves open confirmation in dedicated RCTs.

Structured PICO

P
Population
Patients with chronic kidney disease (CKD) and heart failure with preserved ejection fraction (HFpEF)

This review highlights the bidirectional relationship between CKD and HFpEF and discusses the emerging role of SGLT2 inhibitors in managing both conditions.

Cite This Study

Mark et al. (2022) conducted a review in Heart failure with preserved ejection fraction (HFpEF) and chronic kidney disease (CKD). Sodium-glucose cotransporter 2 (SGLT2) inhibitors was evaluated. Sodium-glucose cotransporter 2 inhibition offers a novel evidence-based therapy that improves outcomes in patients with heart failure with preserved ejection fraction and chronic kidney disease.

synapsesocial.com/papers/6a0efd6db7cc3b883f22f542https://doi.org/10.1093/ckj/sfac146

Topics

HFpEF management
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