What question did this study set out to answer?

To determine the diagnostic validity of heart failure classifications derived from linked population-based administrative registers compared with independent expert physician adjudication.

February 6, 2012European Journal of Preventive CardiologyOpen Access

The validity of heart failure diagnoses obtained from administrative registers

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Heart failure. Intervention: Administrative registers vs. Physician classification (gold standard). Primary outcome: Validity of heart failure diagnoses (specificity, sensitivity, PPV, NPV).

View Full Paper

Ask AI

Bookmark

Key result

Heart failure diagnoses obtained from administrative registers showed high specificity (99.7%) and positive predictive value (85.9%), but modest sensitivity (48.5%) compared to physician assessment.

Why the study?

Does heart failure diagnosis obtained from administrative registers accurately identify true heart failure cases compared to physician classification?

Population

Participants from the FINRISK 1997 survey in Finland

Comparison

Heart failure diagnosis obtained by record… vs Gold standard classification by three…

Design

Cross-sectional, Independent assessment by two physicians, with discrepant…

Authors

MMMarkku MähönenUniversity of Oulu AJAntti JulaPreventive Cardiology KHKennet HaraldFinnish Institute for Health and Welfare

Discussion

Member takes

Implication

Supports register-based HF endpoints in research; leaves open utility for prevalence estimates given modest sensitivity.

Key Points

To determine the diagnostic validity of heart failure classifications derived from linked population-based administrative registers compared with independent expert physician adjudication.
Linked Finnish nationwide databases (Hospital Discharge Register, Causes of Death Register, Drug Reimbursement Register, and pharmacy data) with the FINRISK 1997 survey.
Established a gold standard reference through independent assessment by up to three physicians for cases with prior hospitalization, heart failure medication reimbursement, furosemide, digoxin, or baseline brain natriuretic peptide > 100 pg/ml.
Register classification achieved a specificity of 99.7% (95% CI 99.5-99.8%) and a sensitivity of 48.5% (95% CI 42.9-54.2%).
The positive predictive value was 85.9% (95% CI 79.7-90.5%) and the negative predictive value was 97.9% (95% CI 97.6-98.2%).

Study Design

Type

Observational

Multicenter

Yes

Structured PICO

Does heart failure diagnosis obtained from administrative registers accurately identify true heart failure cases compared to physician classification?

Population

Participants from the FINRISK 1997 survey in Finland

Intervention

Heart failure diagnosis obtained by record linkage of administrative databases (Hospital Discharge Register, Causes of Death Register, Drug Reimbursement Register, and pharmacy prescription data)

Comparator

Gold standard classification by three independent physicians

Outcome

Validity of heart failure diagnoses (specificity, sensitivity, positive predictive value, negative predictive value)

Administrative registers provide highly specific but modestly sensitive identification of heart failure cases, supporting their use for clinical endpoints but cautioning against their use for population surveillance.

Limitations

Modest sensitivity means administrative data should be used with caution for surveillance.

Cite This Study

Mähönen et al. (2012) conducted an observational in Heart failure. Administrative registers vs. Physician classification (gold standard) was evaluated on Validity of heart failure diagnoses (specificity, sensitivity, PPV, NPV). Heart failure diagnoses obtained from administrative registers showed high specificity (99.7%) and positive predictive value (85.9%), but modest sensitivity (48.5%) compared to physician assessment.

synapsesocial.com/papers/6a0efd6db7cc3b883f22f559 https://doi.org/10.1177/2047487312438979

Topics

Heart failure HFrEF treatment Heart failure hospitalization

View Full Paper

Ask AI

Bookmark

The validity of heart failure diagnoses obtained from administrative registers

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Limitations

Cite This Study

Topics

The validity of heart failure diagnoses obtained from administrative registers

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider