Key result
In healthy adults, plasma BNP levels were significantly higher in women compared to men (12.2 vs 7.7 pg/ml), and both ANP and BNP levels increased significantly with age.
Why the study?
Do age and sex affect circulating levels of cardiac natriuretic hormones in healthy adults?
Population
216 healthy adults, age 20-77 years, non-obese, with normal arterial blood pressure and free from acute…
Design
Cross-sectional
Authors
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Age- and sex-specific BNP reference values may be needed; leaves open effects on diagnostic thresholds.
Cross-Sectional (n=216)
No
Do age and sex affect circulating levels of cardiac natriuretic hormones in healthy adults?
Absolute Event Rate: 12.2% vs 7.7%
p-value: p=<0.0001
Aging and female sex independently increase ANP and BNP levels in healthy adults, highlighting the need for age- and sex-specific reference values.
Clerico et al. (2002) conducted a cross-sectional in Healthy adults (n=216). Female sex vs. Male sex was evaluated on Mean BNP value (pg/ml) (p=<0.0001). In healthy adults, plasma BNP levels were significantly higher in women compared to men (12.2 vs 7.7 pg/ml), and both ANP and BNP levels increased significantly with age.
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