Key result
Plasma levels of adrenomedullin, atrial natriuretic peptide, and brain natriuretic peptide all increased significantly with age in a general population without overt cardiovascular disease.
Population
184 local residents with no apparent cardiovascular diseases undergoing a scheduled regular health checkup
Design
Cross-sectional
Authors
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Age and pulse pressure associate with higher AM, ANP, and BNP in healthy adults; leaves open their role as early biomarkers of vascular aging.
Cross-Sectional (n=184)
No
p-value: p=<0.001
In a general population without apparent cardiovascular disease, plasma levels of AM, ANP, and BNP increase with age, and ANP and BNP correlate with pulse pressure, reflecting age-related cardiovascular changes.
Kato et al. (2002) conducted a cross-sectional in General population without overt cardiovascular disease (n=184). Age and pulse pressure was evaluated on Association of plasma levels of adrenomedullin (AM), atrial natriuretic peptide (ANP), and brain natriuretic peptide (BNP) with age (p=<0.001). Plasma levels of adrenomedullin, atrial natriuretic peptide, and brain natriuretic peptide all increased significantly with age in a general population without overt cardiovascular disease.
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