Why the study?
Does adjunctive CFAE ablation added to PVI improve freedom from atrial fibrillation or other atrial tachyarrhythmias in patients with atrial fibrillation?
Population
538 patients with atrial fibrillation from 6 randomized controlled trials
Comparison
Pulmonary vein isolation plus complex… vs Pulmonary vein isolation (PVI) alone
Design
Meta-analysis
Follow-up
≥3 months
Key result
Adjunctive complex fractionated atrial electrogram ablation plus pulmonary vein isolation improved freedom from atrial tachyarrhythmias compared to PVI alone (OR 2.0; 95% CI 1.04-3.8; P=0.04).
Authors
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Supports adjunctive CFAE ablation during PVI for AF; extends pooled RCT evidence despite longer procedure times.
Meta-Analysis (n=538)
Does adjunctive CFAE ablation added to PVI improve freedom from atrial fibrillation or other atrial tachyarrhythmias in patients with atrial fibrillation?
Effect estimate: OR 2.0 (95% CI 1.04-3.8)
p-value: p=0.04
Adjunctive CFAE ablation combined with PVI significantly increases freedom from atrial arrhythmias compared to PVI alone, though at the cost of longer procedural and fluoroscopy times.
Kong et al. (2010) conducted a meta-analysis in Atrial fibrillation (n=538). Pulmonary vein isolation plus complex fractionated atrial electrogram ablation (PVI+CFAE) vs. Pulmonary vein isolation (PVI) alone was evaluated on Freedom from AF or other atrial tachyarrhythmias (ATs) after a single ablation with or without antiarrhythmic drugs (OR 2.0, 95% CI 1.04-3.8, p=0.04). Adjunctive complex fractionated atrial electrogram ablation plus pulmonary vein isolation improved freedom from atrial tachyarrhythmias compared to PVI alone (OR 2.0; 95% CI 1.04-3.8; P=0.04).