Key result
In a canine model of chronic left atrial dilatation, conduction velocity in the left atrial posterior wall was significantly decreased (0.87 vs 1.06 m/s, p<0.01) and associated with increased interstitial fibrosis and atrial fibrillation inducibility.
Why the study?
Does chronic left atrial dilatation alter the electrophysiology and tissue structure of the left atrial posterior wall in a canine model?
Does chronic left atrial dilatation alter the electrophysiology and tissue structure of the left atrial posterior wall in a canine model?
Absolute Event Rate: 0.87% vs 1.06%
p-value: p=<0.01
Chronic left atrial dilatation in a canine model leads to electrophysiological and structural changes in the left atrial posterior wall, increasing vulnerability to atrial fibrillation.
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Does not inform clinical AF management; leaves open whether posterior wall fibrosis drives human arrhythmia.
Tang et al. (2007) studied Chronic left atrial dilatation (CDLA) and Atrial Fibrillation (n=16). Creation of mitral regurgitation (CDLA model) vs. Control dogs was evaluated on Conduction velocity at the left atrial posterior wall (m/s) (p=<0.01). In a canine model of chronic left atrial dilatation, conduction velocity in the left atrial posterior wall was significantly decreased (0.87 vs 1.06 m/s, p<0.01) and associated with increased interstitial fibrosis and atrial fibrillation inducibility.
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