Why the study?
Non-adherence to antihypertensive treatment is a common cause of treatment failure linked with increased cardiovascular risk, but an ideal method to identify non-adherent patients in daily practice has not yet been established.
What is a practical approach to assess non-adherence to antihypertensive treatment in clinical practice?
What is a practical approach to assess non-adherence to antihypertensive treatment in clinical practice?
Provides a practical algorithm for clinicians to detect non-adherence to antihypertensive therapy, emphasizing chemical adherence testing as the optimal method.
Supports chemical testing for non-adherence assessment in hypertension; leaves open prospective trials on clinical outcomes.
Non-adherence to antihypertensive treatment is frequent, complicates the care of hypertensive patients, represents one of the major causes of treatment failure and is linked with the increased risk of cardiovascular events. Identifying a non-adherent patient is one of the recent daily-practice tasks for which the ideal solution has not yet been found. Presence of certain clinical red flags should prompt the clinician to consider non-adherence. Chemical adherence testing using serum or urine antihypertensive levels is regarded as the best method so far and should be used if available. Alternatively, the check for prescription refills in the patient electronic medical records, or directly observed therapy with subsequent ambulatory blood pressure monitoring may be used. We suggest a simple algorithm to guide the clinicians to detect non-adherence in the practice.
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Kociánová et al. (2023) studied this question.
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