Quantification of Diffuse Myocardial Fibrosis and Its Association With Myocardial Dysfunction in Congenital Heart Disease
Key result
Cardiac MRI-derived diffuse fibrosis index was significantly elevated in patients with adult congenital heart disease compared to normal controls (31.9% vs 24.8%; P=0.001).
Why the study?
Does cardiac MRI with gadolinium identify elevated diffuse myocardial fibrosis in adults with congenital heart disease compared to healthy controls?
Population
50 patients with adult congenital heart disease, including 11 with systemic right ventricle, 17 with…
Comparison
Cardiac MRI with gadolinium to quantify diffuse… vs Healthy volunteers and patients with acquired…
Design
Cross-sectional
Authors
Discussion
Loading...
Member takes
Implication
Elevated diffuse fibrosis on cardiac MRI in adult congenital heart disease may mark ventricular dysfunction; extends acquired heart failure observations but leaves clinical utility open.
Study Design
Type
Cross-Sectional (n=68)
Structured PICO
Does cardiac MRI with gadolinium identify elevated diffuse myocardial fibrosis in adults with congenital heart disease compared to healthy controls?
P
Population
50 patients with adult congenital heart disease (ACHD) (mean age 37±12 years, 40% female), including 11 with systemic right ventricle, 17 with tetralogy of Fallot, 10 with cyanosis, and 12 with other lesions. Also included 14 healthy volunteers and 4 patients with acquired heart failure.
I
Intervention
Cardiac MRI with gadolinium (0.15 mmol/kg) to quantify diffuse fibrosis (fibrosis index)
C
Comparator
Healthy volunteers (normal controls, n=14) and patients with acquired heart failure (positive controls, n=4)
O
Outcome
Fibrosis index (quantified by measuring T1 values for blood pool and myocardium before and after gadolinium, adjusted for hematocrit)surrogate
Main Result
Absolute Event Rate: 31.9% vs 24.8%
p-value: p=0.001
Patients with adult congenital heart disease have elevated diffuse myocardial fibrosis measured by MRI, which correlates with ventricular dysfunction.
Cite This Study
Broberg et al. (2010) conducted a cross-sectional in Adult congenital heart disease (n=68). Cardiac MRI for quantification of diffuse fibrosis (fibrosis index) vs. Healthy volunteers and patients with acquired heart failure was evaluated on Fibrosis index (p=0.001). Cardiac MRI-derived diffuse fibrosis index was significantly elevated in patients with adult congenital heart disease compared to normal controls (31.9% vs 24.8%; P=0.001).