Key result
Low albumin to fibrinogen ratio linked to ~215% greater risk of HCM-related death.
Why the study?
Whether the albumin to fibrinogen ratio could serve as a useful indicator to predict mortality in patients with hypertrophic cardiomyopathy remained to be evaluated.
Does a low baseline albumin to fibrinogen ratio predict increased HCM-related death in adult patients with hypertrophic cardiomyopathy?
Cohort (n=404)
No
Does a low baseline albumin to fibrinogen ratio predict increased HCM-related death in adult patients with hypertrophic cardiomyopathy?
Effect estimate: HR 3.15 (95% CI 0.16-0.64)
Absolute Event Rate: 16.34% vs 5.94%
p-value: p=0.001
Background Albumin to fibrinogen ratio (AFR) has emerged as a useful indicator for adverse outcomes in several diseases. However, whether the AFR could be a new useful indicator to predict mortality in HCM patients remains to be evaluated. The study investigated the predictive value of the AFR for HCM-related death in adult HCM patients. Methods A total of 404 HCM patients were retrospectively enrolled. Patients were divided into two groups based on the median of baseline AFR. The association between AFR and HCM-related death was analyzed. Results During a median follow-up duration of 4.75 years, 45 patients (11.1%) occurred in HCM-related death. The incidence of HCM-related death was significantly higher in the low AFR group (Log-rank p < 0.001). With the high AFR group as reference, the fully adjusted hazard ratios (HRs) of HCM-related death were 3.15 for the low AFR group (95% confidence interval [CI]: 0.16–0.64, p = 0.001). No significant interactions between AFR and other variables were observed in subgroup analysis. Sensitivity analyses in patients with normal albumin and fibrinogen have showed similar results. Conclusion AFR is an independent prognostic factor for HCM-related death in adult HCM patients.
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Li et al. (2023) conducted a cohort in Hypertrophic cardiomyopathy (n=404). Low albumin to fibrinogen ratio (AFR < 15.94) vs. High albumin to fibrinogen ratio (AFR ≥ 15.94) was evaluated on HCM-related death (HR 3.15, 95% CI 0.16-0.64, p=0.001). A low albumin to fibrinogen ratio was associated with a significantly increased risk of HCM-related death compared to a high ratio (HR 3.15) in adult patients with hypertrophic cardiomyopathy.
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