Key result
Combination half-dose t-PA with streptokinase yielded superior 90-minute infarct vessel patency (79% vs 64%, p<0.05) compared with conventional full-dose t-PA in myocardial infarction.
Why the study?
Does combination half-dose t-PA and streptokinase improve 90-minute infarct vessel patency in patients with acute myocardial infarction compared to full-dose t-PA?
RCT (n=216)
Yes
Does combination half-dose t-PA and streptokinase improve 90-minute infarct vessel patency in patients with acute myocardial infarction compared to full-dose t-PA?
Absolute Event Rate: 79% vs 64%
p-value: p=<0.05
A combination of half-dose t-PA and streptokinase provides superior 90-minute coronary patency compared to full-dose t-PA in acute myocardial infarction.
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May support combination thrombolysis for early reperfusion in acute MI; extends prior fibrinolytic comparisons in this RCT.
Grines et al. (1991) conducted an RCT in myocardial infarction (n=216). tissue-type plasminogen activator (t-PA) and streptokinase (SK) vs. t-PA (100 mg) during 3 hours was evaluated on Acute patency at 90 minutes (p=<0.05). Combination half-dose t-PA with streptokinase yielded superior 90-minute infarct vessel patency (79% vs 64%, p<0.05) compared with conventional full-dose t-PA in myocardial infarction.
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