Key result
Exercise-induced ST changes for detecting CAD had 85% sensitivity and 100% specificity in patients with normal resting ECGs, but decreased to 76% and 79% in those with abnormal ECGs not on drugs.
Why the study?
Does a maximum graded treadmill exercise test accurately detect coronary artery disease in patients with abnormal control electrocardiograms compared to those with normal control electrocardiograms?
Observational (n=178)
Does a maximum graded treadmill exercise test accurately detect coronary artery disease in patients with abnormal control electrocardiograms compared to those with normal control electrocardiograms?
Absolute Event Rate: 76% vs 85%
Exercise-induced ST changes are highly valid for diagnosing CAD in patients with normal resting ECGs or abnormal ECGs without non-nitrate drug therapy, but lose diagnostic utility in patients with abnormal ECGs taking other cardiovascular drugs.
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Exercise ST changes warrant cautious use with abnormal resting ECGs; leaves open prospective validation of accuracy.
Linhart et al. (1974) conducted an observational in Coronary artery disease (n=178). Maximum graded treadmill exercise test vs. Normal control ECG was evaluated on Sensitivity of exercise-induced ST changes for coronary artery disease. Exercise-induced ST changes for detecting CAD had 85% sensitivity and 100% specificity in patients with normal resting ECGs, but decreased to 76% and 79% in those with abnormal ECGs not on drugs.
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