What question did this study set out to answer?

Establish fundamental chronic dose-response carcinogenicity data for dietary fumonisin B1 in rats and mice to guide regulatory food safety standards.

May 1, 2001Environmental Health PerspectivesOpen Access

Fumonisin b1 carcinogenicity in a two-year feeding study using F344 rats and B6C3F1 mice.

View Full Paper

Ask AI

Bookmark

Establish fundamental chronic dose-response carcinogenicity data for dietary fumonisin B1 in rats and mice to guide regulatory food safety standards.
F344/N/Nctr BR rats and B6C3F1 Nctr BR mice of both sexes received powdered NIH-31 diets formulated with varied concentrations of fumonisin B1 for two years.
Dietary exposures ranged across cohorts: female rats received 0, 5, 15, 50, or 100 ppm; male rats received 0, 5, 15, 50, or 150 ppm; female mice received 0, 5, 15, 50, or 80 ppm; and male mice received 0, 5, 15, 80, or 150 ppm.
In male rats, fumonisin B1 induced renal tubule adenomas and carcinomas at rates of 0/48 (0 ppm), 0/40 (5 ppm), 9/48 (50 ppm), and 15/48 (150 ppm), whereas female rats developed no tumors up to 100 ppm.
In female mice, fumonisin B1 caused hepatocellular adenomas and carcinomas in 5/47 (0 ppm), 3/48 (5 ppm), 1/48 (15 ppm), 19/47 (50 ppm), and 39/45 (80 ppm) animals, while male mice showed no tumor elevation up to 150 ppm.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Two-year feeding study reveals sex- and species-specific carcinogenicity of dietary fumonisin B1 in rodents, highlighting critical dose-response thresholds for food safety guidelines.

Cite This Study

Howard et al. (2001) studied this question.

synapsesocial.com/papers/6a0f2797a7a2fed64abdc302 https://doi.org/10.1289/ehp.01109s2277

View Full Paper

Ask AI

Bookmark

Implication

Two-year feeding study reveals sex- and species-specific carcinogenicity of dietary fumonisin B1 in rodents, highlighting critical dose-response thresholds for food safety guidelines.

Fumonisin b1 carcinogenicity in a two-year feeding study using F344 rats and B6C3F1 mice.

Key Points

Discussion

Implication

Cite This Study

Fumonisin b1 carcinogenicity in a two-year feeding study using F344 rats and B6C3F1 mice.

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider