Key result
High-dose ACE inhibitor therapy in heart failure patients resulted in significant reductions in all-cause mortality or hospitalization, cardiovascular hospitalizations, and heart failure hospitalizations.
Why the study?
Does high-dose ACE inhibitor therapy improve clinical outcomes and functional capacity compared to lower doses in patients with heart failure?
Population
Patients with heart failure
Comparison
High-dose angiotensin-converting enzyme inhibitors vs Lower doses of ACE inhibitors
Design
Review
Authors
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Should not yet change ACE inhibitor dosing in heart failure; leaves open need for randomized confirmation.
Does high-dose ACE inhibitor therapy improve clinical outcomes and functional capacity compared to lower doses in patients with heart failure?
Clinicians should attempt to reach target doses of ACE inhibitors in heart failure whenever possible, as higher doses are associated with better clinical outcomes and functional capacity.
Thomas et al. (2006) conducted a review in Heart failure. Angiotensin-converting enzyme (ACE) inhibitors vs. Lower doses was evaluated on Neurohormonal, functional capacity, and clinical outcomes. High-dose ACE inhibitor therapy in heart failure patients resulted in significant reductions in all-cause mortality or hospitalization, cardiovascular hospitalizations, and heart failure hospitalizations.
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