Catheter ablation for atrial fibrillation is associated with lower incidence of heart failure and death
Key result
AF catheter ablation is linked to ~31% lower all-cause mortality and reduced HF risk.
- HR 0.69
- P<0.001
- n=25,439
Why the study?
Catheter ablation for atrial fibrillation improves symptoms, but whether it improves clinical outcome remains less clear.
Does catheter ablation for atrial fibrillation reduce death, stroke, or incident heart failure in patients with previous direct current cardioversion?
Population
25 439 patients undergoing their 1st DC cardioversion for AF
Comparison
Catheter ablation for AF vs no catheter ablation
Design
Nationwide cohort study
Follow-up
Median 5.3 years
Authors
Discussion
Loading...
Member takes
Implication
Ablation associated with lower death and HF risks post-cardioversion; hypothesis-generating and requires RCT confirmation before practice change.
Study Design
Type
Cohort (n=25,439)
Multicenter
Yes
Structured PICO
Does catheter ablation for atrial fibrillation reduce death, stroke, or incident heart failure in patients with previous direct current cardioversion?
P
Population
25,439 patients who underwent their 1st direct current cardioversion for atrial fibrillation in the period 2003-15
I
Intervention
Catheter ablation for atrial fibrillation (n=3,509)
C
Comparator
No catheter ablation (assessed using time-varying covariate and propensity-matched cohort)
O
Outcome
All-cause death, cardiovascular death, stroke/thromboembolism, and incident heart failure (HF)hard clinical
Main Result
Effect estimate: HR 0.69
p-value: p=<0.001
In patients with atrial fibrillation and prior direct current cardioversion, catheter ablation is associated with a reduced risk of all-cause death, cardiovascular death, and incident heart failure.
Cite This Study
Modin et al. (2019) conducted a cohort in Atrial fibrillation with previous direct current cardioversion (n=25,439). Catheter ablation for atrial fibrillation vs. No catheter ablation was evaluated on All-cause death (HR 0.69, p=<0.001). Catheter ablation for atrial fibrillation was associated with reduced risks of all-cause death (HR 0.69, P<0.001), cardiovascular death (HR 0.68), and incident heart failure (HR 0.76).