Key result
MRI-depicted thin and/or ruptured fibrous cap was strongly associated with recurrent ipsilateral TIA or stroke at 1 year (HR 5.756; 95% CI 1.913-17.324; P=0.002).
Why the study?
Does multisequence carotid plaque MRI predict the recurrence of ipsilateral TIA and/or stroke in previously symptomatic patients with 30-69% carotid stenosis?
Cohort (n=126)
Does multisequence carotid plaque MRI predict the recurrence of ipsilateral TIA and/or stroke in previously symptomatic patients with 30-69% carotid stenosis?
Effect estimate: HR 5.756 (95% CI 1.913-17.324)
p-value: p=0.002
Carotid plaque MRI features, including a thin or ruptured fibrous cap, intraplaque hemorrhage, and lipid-rich necrotic core, can identify patients with moderate carotid stenosis who are at high risk for recurrent TIA or stroke.
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May support plaque MRI for risk stratification in moderate stenosis; leaves open whether features should guide intervention.
Kwee et al. (2012) conducted a cohort in Transient ischemic attack (TIA) and stroke (n=126). Carotid plaque MRI (assessing LRNC, FC status, and IPH) was evaluated on Recurrence of ipsilateral TIA and/or stroke (HR 5.756, 95% CI 1.913-17.324, p=0.002). MRI-depicted thin and/or ruptured fibrous cap was strongly associated with recurrent ipsilateral TIA or stroke at 1 year (HR 5.756; 95% CI 1.913-17.324; P=0.002).