Key result
Active cancer in ischemic stroke patients was associated with a higher frequency of unidentified stroke etiology (P<0.001) and multiple vascular territory infarctions (P<0.001) compared to controls.
Why the study?
Are the etiology, risk factors, and imaging/biomarker profiles of ischemic stroke different in patients with active malignant cancer compared to those without?
Population
280 patients with ischemic stroke, comprising 140 patients with active and malignant cancer and 140 age- and…
Comparison
Active and malignant cancer (exposure) vs Age- and sex-matched control group of stroke…
Design
Case-control
Authors
Loading...
May prompt malignancy evaluation in cryptogenic multi-territory stroke; leaves open whether screening improves outcomes.
Case-Control (n=280)
No
Are the etiology, risk factors, and imaging/biomarker profiles of ischemic stroke different in patients with active malignant cancer compared to those without?
p-value: p=<0.001
Cancer-associated hypercoagulation is a significant etiology for ischemic stroke, particularly in patients presenting with elevated d-dimer levels, multiple territory infarctions, and lacking conventional stroke risk factors.
Schwarzbach et al. (2012) conducted a case-control in Ischemic stroke and active malignant cancer (n=280). Active and malignant cancer vs. Age- and sex-matched control group was evaluated on Unidentified stroke etiology (p=<0.001). Active cancer in ischemic stroke patients was associated with a higher frequency of unidentified stroke etiology (P<0.001) and multiple vascular territory infarctions (P<0.001) compared to controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: