Warfarin Discontinuation After Starting Warfarin for Atrial Fibrillation
Population
4,188 subjects newly starting warfarin for atrial fibrillation in the Anticoagulation and Risk Factors in…
Design
Cohort
Follow-up
1 year
Authors
Discussion
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Member takes
Implication
High discontinuation rates highlight adherence challenges in AF; leaves open whether targeted interventions improve persistence in younger or low-risk patients.
Structured PICO
P
Population
4,188 subjects newly starting warfarin for atrial fibrillation in the Anticoagulation and Risk Factors in Atrial Fibrillation Study
I
Intervention
Warfarin
O
Outcome
Prolonged warfarin discontinuation, defined as ≥180 consecutive days off warfarin
More than 1 in 4 patients newly starting warfarin for atrial fibrillation discontinue therapy within the first year, particularly younger patients, those with poor INR control, and those with lower stroke risk.
Cite This Study
Fang et al. (2010) studied this question.