Key result
Top-quartile NT-proBNP is linked to ~190% higher ischemic stroke risk versus the bottom quartile.
Why the study?
Does higher baseline NT-proBNP level predict an increased risk of incident ischemic stroke in a general population cohort?
Cohort (n=1,502)
Yes
Does higher baseline NT-proBNP level predict an increased risk of incident ischemic stroke in a general population cohort?
Effect estimate: HR 2.9 (95% CI 1.9-4.5)
Elevated baseline NT-proBNP is a strong, independent risk marker for incident ischemic stroke, particularly cardioembolic stroke, suggesting its potential utility in primary prevention risk stratification.
NT-proBNP elevation marks higher ischemic stroke risk in cohorts; leaves open utility for primary prevention stratification.
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Cushman et al. (2014) conducted a cohort in Stroke risk (n=1,502). NT-proBNP (top quartile) vs. NT-proBNP (bottom quartile) was evaluated on Incident ischemic stroke (HR 2.9, 95% CI 1.9-4.5). Participants with baseline NT-proBNP in the top versus the bottom quartile had a significantly increased risk of incident ischemic stroke (HR 2.9; 95% CI 1.9-4.5) over 5.4 years of follow-up.
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