Key result
PFO-related strokes more frequently presented as single cortical infarctions (34.2% vs 3.1%; P<0.001) or multiple small scattered lesions compared to AF-related strokes.
Why the study?
Do the neuroimaging characteristics of ischemic stroke differ between patients with patent foramen ovale and those with atrial fibrillation?
Population
475 patients with ischemic stroke, comprising 117 patients with PFO-stroke and 358 patients with AF-stroke…
Comparison
Ischemic stroke caused by patent foramen ovale vs Ischemic stroke caused by atrial fibrillation (AF)
Design
Cohort
Authors
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May aid PFO vs AF etiology differentiation in cryptogenic stroke; leaves open prospective validation before diagnostic algorithms change.
Observational (n=475)
Do the neuroimaging characteristics of ischemic stroke differ between patients with patent foramen ovale and those with atrial fibrillation?
Absolute Event Rate: 34.2% vs 3.1%
p-value: p=<0.001
PFO-related strokes exhibit distinct neuroimaging patterns compared to AF-related strokes, typically presenting as single cortical or multiple small lesions in the vertebrobasilar circulation without visible vessel occlusion, which may aid in diagnosing the underlying etiology.
Kim et al. (2013) conducted an observational in Ischemic stroke (n=475). PFO-stroke vs. AF-stroke was evaluated on Single cortical infarction (p=<0.001). PFO-related strokes more frequently presented as single cortical infarctions (34.2% vs 3.1%; P<0.001) or multiple small scattered lesions compared to AF-related strokes.
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