Key result
Sustained elevation of plasma BNP from day 30 to day 90 post-myocardial infarction identified patients with progressive ventricular remodelling with 100% sensitivity and 83% specificity.
Why the study?
Does sustained elevation of plasma BNP predict progressive left ventricular remodeling after acute myocardial infarction?
Observational (n=21)
Does sustained elevation of plasma BNP predict progressive left ventricular remodeling after acute myocardial infarction?
Effect estimate: r=0.70
p-value: p=<0.001
Sustained elevation of plasma BNP in the chronic phase after acute myocardial infarction is strongly associated with progressive left ventricular remodeling.
No takes yet. Share an insight, caveat, or question.
May support serial BNP monitoring to flag post-MI remodeling risk; hypothesis-generating and requires prospective validation.
Nagaya et al. (1999) conducted an observational in Acute myocardial infarction (n=21). Plasma brain natriuretic peptide (BNP) measurement vs. Non-remodelling group was evaluated on Left ventricular remodelling (increase in EDVI ≥5 ml/m2 from acute to chronic phase) (r=0.70, p=<0.001). Sustained elevation of plasma BNP from day 30 to day 90 post-myocardial infarction identified patients with progressive ventricular remodelling with 100% sensitivity and 83% specificity.
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